|
Professional
Experience
| 1999-Present |
Associate
Professor, Department of Cell and Developmental Biology and
Anatomy, University of S.C. School of Medicine |
| 1993-99
|
Assistant
Professor, Dept Developmental Biology &Anatomy, Univ of
S.C. School of Medicine |
| 1990-93
|
Research
Assistant Professor, Dept Developmental Biology & Anatomy,
Univ of S.C. School of Medicine |
| 1988-90 |
Postdoc,
Department of Pathology, University of S.C. School of Medicine,
Lab of Dr. Thomas K. Borg |
Research
Interest
Dr.
Carver's research focuses on the organization of various cell types
in the developing heart and the possible effect on heart development
of alterations in this organization. Interactions between adjacent
cells and between cells and the surrounding matrix are critical
in establishing the three-dimensional organization of cells within
the heart. Several model systems are being used to determine the
role of specific cell surface molecules, including cadherins and
integrins, in these cell-cell and cell- matrix interactions during
heart development. Experiments are also being carried out to examine
the roles of various chemical and physical factors in regulating
the expression of these important cell surface molecules. The goal
of these studies is to understand how specific cell surface components
may mediate the organization of the heart and how these molecules
are regulated during development.
Professional
Memberships
American Society of Cell Biologists
South Carolina Academy of Sciences
International Society of Medical Science Educators
Society of Developmental Biology
Professional Service
NIH-HLBI, Cardiovascular
A ad hoc member
NIH-HLBI, Cardiovascular Training Grant ad hoc
AHA, Basic Cell and Molecular Biology
AHA, Mid-Atlantic Affiliate CV Development
Recent
Publications
Atance,
J, MJ Yost and W Carver (2004). Influence of the extracellular
matrix on the regulation of cardiac fibroblast behavior by
mechanical stretch. J. Cell Physiol. 200:377-386. |
Borck,
A, E Massey, MJ Loftis and W Carver (2004). Exposure of cardiac
fibroblasts to the herbicide nitrofen causes altered interactions
with the extracellular matrix. Cell Biol. Toxicol. 20: 15-24. |
G.
Diaz-Araya, T.K. Borg, S. Lavandero and W. Carver (2003).
IGF-1 modulation of rat cardiac fibroblast behavior and gene
expression is age-dependent. Cell Adhesion Communication .
10: 155 –165. |
Loftis,
MJ, D Sexton and W Carver (2003). Effects of collagen density
on cardiac fibroblast behavior and gene expression. J. Cell.
Physiol. 196:504-511. |
de
Almeida, A, D Mustin, M Forman, GL Brower, JS Janicki and
W Carver (2002). Effects of mast cells on the behavior of
isolated heart fibroblasts: Modulation of collagen remodeling
and gene expression. J. Cell. Physiology 191:51-59. |
Goldsmith,
EC, W Carver, A McFadden, JG Goldsmith, RL Price, M. Sussman,
BH Lorell and TK Borg (2002). Integrin shedding as a mechanism
of cellular adaptation during cardiac growth. Amer. J. Physiol.
Heart Circ. Physiol. 284:H2227- H22234. |
Kanekar,
S, TK Borg, L Terracio and W Carver (2000). Modulation of
heart fibroblast migration and collagen gel contraction by
IGF-I. Cell Adhesion & Commun. 6:513-523. |
Borg,
TK, EC Goldsmith, R Price, W Carver, L Terracio and AM Samarel
(2000). Specialization at the Z line of cardiac myocytes.
Cardiovascular Res. 46:277-285. |
|
