LaVoie

Welcome to the School of Medicine


	FACULTY
	STAFF
	STUDENTS
	RESEARCH
	CDBA HOME
	SOM HOME

Holly A. LaVoie, Ph.D.
Associate Professor
Phone: (803) 733-1575
Fax: (803) 733-1533
hlavoie@uscmed.sc.edu
Lab Page under construction

Professional Experience

1999 - present	Assistant Professor, University of South Carolina School of Medicine
1998-1999	Assistant Professor of Biological Sciences, University of Maine, Orono
1994-1997	Postdoctoral Research Fellow, University of Virginia

Research Interests

Dr. LaVoie’s research aims to elucidate mechanisms of multi-hormonal control of critical genes involved in ovarian cell differentiation and progesterone biosynthesis. Ongoing studies involve determining how IGF-I augments gonadotropin (FSH and LH) actions. One area of focus is the regulation of the Steroidogenic Acute Regulatory Protein (StAR) and how these hormones regulate its activation via transcription factors including GATA-4/-6, CEBP, and SF-1. Other areas of interest focus on the role of estradiol in luteal cell function. Dr. LaVoie’s laboratory uses the pig as its model system because its utilization of LDL cholesterol in the production of steroid hormones is similar to humans.

Professional Memberships

Society for the Study of Reproduction
The Endocrine Society
Society for Experimental Biology and Medicine

Recent Publications

Gillio-Meina, C., Hui, Y.Y., and LaVoie, H.A. Expression of CCAAT/enhancer binding proteins alpha and beta in the porcine ovary and regulation in primary granulosa cell cultures. Biol Reprod, 2005 in press.

Rusovici, R., Hui, Y.Y., and LaVoie, H.A. EGF-mediated inhibition of FSH-stimulated StAR gene expression in porcine granulosa cells is associated with reduced histone H3 acetylation. Biol Reprod, 2005 in press.

LaVoie, H.A., McCoy, G.L., and Blake, C.A. Expression of GATA-4 and GATA-6 in the rat fetal gonad and the ovary during development and pregnancy. Mol Cell Endocrinol 227:31-40, 2004.

LaVoie, H.A., Singh, D., and Hui, Y.Y. Concerted regulation of the porcine StAR gene promoter activity by FSH and IGF-I in granulosa cells involves GATA-4 and C/EBPb. Endocrinology 145:3122-3134, 2004.

LaVoie, H.A. The role of GATA in mammalian reproduction. Exp Biol Med (Maywood) Review. 228:1282-1290, 2003.

Blake, C.A., LaVoie, H.A., and Millette, C.F. Teaching medical histology at the University of South Carolina School of Medicine: transition to virtual slides and virtual microscopes. Anat Record (New Anatomist) 175B:196-206, 2003.

Rusovici, R. and LaVoie, H.A. Expression and distribution of AP-1 transcription factors in the porcine ovary. Biol Reprod 69:64-74, 2003.

Gillio-Meina, C., Hui, Y.Y. and LaVoie, H.A. GATA-4 and GATA-6 transcription factors: expression, immunohistochemical localization, and possible function in the porcine ovary. Biol Reprod 68:412-422, 2003.

LaVoie, H.A., DeSimone, D.C., Gillio-Meina, C., and Hui, Y.Y. Cloning and characterization of porcine ovarian estrogen receptor b isoforms. Biol Reprod 66:616-623, 2002.

Sekar, N., LaVoie, H.A. and Veldhuis, J.D. Concerted regulation of steroidogenic acute regulatory gene expression by luteinizing hormone and insulin (or insulin-like growth factor I) in primary cultures of porcine granulosa-luteal cells. Endocrinology 141:3983-3992, 2000.

RETURN TO TOP

USC LINKS: