Thiruvanamalai image

Valarmathi M. Thiruvanamalai, M.D., Ph.D.

Research Assistant Professor of Cell Biology & Anatomy
University of South Carolina School of Medicine

Contact:
Office:  803-216-3821
Lab:     803-216-3876
Fax:     803-216-3846
Email: valarmathi.thiruvanamalai@uscmed.sc.edu

PubMed
Complete CV

1981-1984

B.Sc., Chemistry, University of Madras (Dowaraka Doss Goverdhan Doss Vaishnav College), Madras, INDIA
1984-1989  M.B.B.S., Medicine & Surgery, University of Madras (Kilpauk Medical College), Madras, INDIA
1991-1994 M.D., Pathology, University of Madras (Postgraduate Institute of Basic Medical Sciences), Madras, INDIA
1998-2003 Ph.D., Biotechnology, All-India Institute of Medical Sciences (A.I.I.M.S.), New Delhi, INDIA
1989-1990 Compulsory Rotary Residential Internships, University of Madras (Kilpauk Medical College), Madras, INDIA
1997-1998  Post M.D./M.S. Training in Medical Biotechnology, All-India Institute of Medical Sciences (A.I.I.M.S.), New Delhi, INDIA
2004-2006  Visiting Scientist(Postdoctoral Fellowship Training), Laboratory of Molecular Biology (LMB), Centre for Cancer Research (CCR),National Cancer Institute (NCI), National Institutes of Health (NIH), Maryland, USA
2006- 2008 Postdoctoral Research Associate, Department of Chemical Engineering & Department of Cell and Developmental Biology & Anatomy, University of South Carolina, South Carolina
Additional Training:
2005 hESC - Short-term Course in Human Embryonic Stem Cell Culture Techniques, Johns Hopkins University, Baltimore, Maryland, USA
2007 FrHESC - Frontiers in Human Embryonic Stem Cells Advance Training Course,
Pittsburg Development Center, Woods Hole, Massachusetts, USA

Research Focus

Dr. Thiruvanamalai is tackling one of the most fundamental problems facing cardiac therapy, creating a vascularized cardiac muscle construct. Cardiovascular disease is a leading cause of significant morbidity and mortality in the United States. Restricted myocardial regeneration after tissue injury and shortage of organs for transplantation are the principal constraints of conventional therapies. Organ tissue engineering, including cardiovascular tissues, has been an area of intense investigation and offers a potential to develop in vitro functional equivalents of native myocardium for tissue repair and to explore novel approaches to treat or prevent cardiac disease. The current major challenge to these approaches has been the inability to vascularize and perfuse the in vitro engineered tissue constructs. Attempts to provide oxygen and nutrients to the cells contained in the biomaterial constructs have had varying degrees of success. Engineering a tissue of clinically relevant magnitude requires the formation of an extensive and stable microvascular networks within the tissue. Since most in vitro engineered tissue constructs do not contain the intricate microvascular structures of native tissue, the cells contained in scaffolds heavily rely on simple diffusion for oxygenation.  To this end, Dr. Thiruvanamalai is in the process of developing an in vitro vascularized cardiac myotube using autologous and/or allogenic, adult, bone marrow stromal stem cells in a three-dimensional (3-D) tubular scaffold, which can be used as a cardiac patch for repairing various types of cardiac lesions.

In addition, Dr. Thiruvanamalai has already created a novel in vitro vascularized bone tissue using autologous and/or allogenic adult stem cells in another 3-D tubular scaffold as replacement tissue for small segmental bone defects and is considered elegant in design and practice.

Dr. Thiruvanamalai’s research is state-of-the-art that promises to lead to the generation of total replacement biologic products for various therapeutic purposes in regenerative medicine. This is the future of medicine where the clinical and industrial applications of these developed 3-D vascularized tissues are endless and not limited to the repair/regeneration of the heart, blood vessels and bone. Also, there is a need for such tissue for the study of basic biological mechanisms and for the use of drug discovery and screening.

Recent Publications

  • Valarmathi MT, Fuseler JW, Goodwin RL, Davis JM, Potts JD. The mechanical coupling of adult marrow stromal stem cells during cardiac regeneration assessed in a 2-D co-culture model. Biomaterials 2011 Apr; 32(11):2834-2850
  • Valarmathi MT, Goodwin RL, Fuseler JW, Davis JM, Yost MJ, Potts JD. A 3-D cardiac muscle construct for exploring adult marrow stem cell based myocardial regeneration. Biomaterials 2010 Apr; 31(12):3185-3200. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2887929/pdf/nihms206471.pdf

  • Kaur G, Valarmathi MT, Potts JD, Jabbari E, Sabo-Attwood S, Wang Q. Regulation of osteogenic differentiation of rat bone marrow stromal cells on 2D nanorod substrates. Biomaterials 2010 Mar;31(7):1732-41.

  • Valarmathi MT, Davis JM, Yost MJ, Goodwin RL, Potts JD. A three-dimensional model of vasculogenesis.  Biomaterials 2009 Feb; 30(6):1098-112.

  • Kaur G, Valarmathi MT, Potts JD, Wang Q. The promotion of osteoblastic differentiation of rat bone marrow stromal cells by a polyvalent plant mosaic virus. Biomaterials 2008 Oct; 29(30): 4074-81.

  • Valarmathi MT, Yost MJ, Goodwin RL, Potts JD. The influence of proepicardial cells on the osteogenic potential of marrow stromal cells in a three-dimensional tubular scaffold. Biomaterials 2008 May; 29(14):2203-16. {2008 The Year in Images}

  • Jabbari E, He X, Valarmathi MT, Sarvestani AS, Xu W. Material properties and bone marrow stromal cells response to in situ crosslinkable RGD-functionalized lactide-co-glycolide scaffolds. J Biomed Mater Res A. 2009 Apr; 89(1):124-37.

  • Valarmathi MT, Yost MJ, Goodwin RL, Potts JD. A three-dimensional tubular scaffold that modulates the osteogenic and vasculogenic differentiation of rat bone marrow stromal cells. Tissue Eng Part A. 2008 Apr; 14(4): 491-504. {With Journal Cover Art

  • Valarmathi MT, Sawhney M, Deo SS, Shukla NK, Das SN. Novel germline mutations in the BRCA1 and BRCA2 genes in Indian breast and breast-ovarian cancer families. Hum Mutat. 2004 Feb;23(2):205.Online Citation: Human Mutation, Mutation in Brief #684 (2004) Online http://www3.interscience.wiley.com/homepages/38515/pdf/mutation/684.pdf

  • Valarmathi, MT, AA, Deo SS, Shukla NK, Das SN. BRCA1 germline mutations in Indian familial breast cancer. Hum Mutat. 2003 Jan; 21 (1) : 98-9 Online Citation: Human Mutation, Mutation in Brief #570 (2002) Onlinehttp://www.interscience.wiley.com/humanmutation/pdf/mutation/570.pdf
    http://onlinelibrary.wiley.com/doi/10.1002/humu.9099/pdf