John F. Eberth, Ph.D.
Assistant Professor Cell Biology & Anatomy
University of South Carolina School of Medicine
Clarkson University – Bachelors of Science in Mechanical Engineering
Clemson University – Masters of Science in Mechanical Engineering
Texas A&M University – Ph.D. in Biomedical Engineering
Mechanical loads, transduced from the extra-cellular space, act on intra-cellular signaling cascades that influence gene expression and temporal tissue structure. The PI’s work, and that of the Translational Biomechanics Lab (TBL) is based on adapting fundamental engineering principles to understand, manipulate, and control the behavior of healthy and diseased cardiovascular tissue.
Accordingly, the PI’s research thrust areas include: Vascular Growth and Remodeling, Long-Term Mechanical Support Therapy, Atherosclerosis, Cardiovascular Birth Defects, 3D Tissue Engineering, Regenerative Medicine, Coronary Artery Bypass Alternatives, Extra-Cellular Matrix Biology, and Mechanisms of Aging.
Bersi MR, Ferruzzi J, Eberth JF, Gleason RL Jr, Humphrey JD (2014) Consistent biomechanical phenotyping of common carotid arteries from seven genetic, pharmacological, and surgical mouse models. Ann Biomed Eng 42:1207-1223
- Biechler SV, Junor L, Evans AN, Eberth JF, Price RL, Potts JD, Yost MJ, Goodwin RL (2014) The impact of flow-induced forces on the morphogenesis of the outflow tract. Front Physiol 5:225.
- Brysch CN, Paterson R, Olivares O, Eberth JF, Robles-Hernandez FC (2014) Chitosan and chitosan composites reinforced with carbon nanostructures. J Alloys Compounds 615S1: S515-521.
- Chen YC and Eberth, JF (2012) Constitutive function, residual stress, and uniform stress in arteries. Journal of Mechanics and the Physics of Solids 60(6): pp. 1145-1157.
- Eberth JF, Cardamone L, Humphrey JD (2011) Evolving Biaxial Mechanical Properties of Mouse Carotid Arteries in Hypertension. Journal of Biomechanics44(14): pp. 2532-2537.
- Eberth JF, Gresham VC, Wilson E, Popovic N, Humphrey JD (2010). Time course of carotid artery growth and remodeling in response to altered pulsatility. AJP Heart and Circulatory Physiology299(6): pp. H1875-H1883.
- Cardamone L, Valentin A, Eberth JF, Humphrey JD (2010). Modeling arterial adaptation to dynamic alterations of pressure and flow patterns on the cardiac cycle.Mathematical Medicine and Biology 27(4): 343-371.