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Thomas K. Borg, Ph.D.
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Title:
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Carolina Distinguished Professor |
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PUBMED Link:
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Borg
TK |
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Research:
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The research in Dr. Borg's laboratory is focused on investigating the role of the
extracellular matrix (ECM) in the heart during normal growth and development and in
certain disease conditions. These investigations involve the biochemical characterization
of the components of the ECM, analysis of specific receptors for these components, and
molecular expression at critical times in heart development or in disease models. A
variety of experimental approaches is used in this research, including whole embryo
culture, isolated cell culture, exercise physiology, morphological analyses by light and
electron microscopy, and molecular biology. |
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Recent Publications:
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- Yost, MJ, D Simpson, K Wrona, S Ridley, HJ Ploehn, TK Borg and L Terracio. 2000. Design
and construction of a uniaxial cell stretcher. Am J Physiol Heart Circ Physiol.
279:H000-H000.
- Price, RL, TE Thielen, TK Borg and L Terracio. 2000. Cardiac defects associated with the
absence of the platelet-derived growth factor alpha receptor in the Patch mouse.
Microscopy & Microanal. 7:56-65.
- Kanekar, S, TK Borg, L Terracio and W Carver. 2000. Modulation of Heart Fibroblast
Migration and Collagen gel Contraction by IGF-I. Cell Adh. & Comm. 6:513-523.
- Borg, TK, EC Goldsmith, R Price, W Carver, L Terracio and AM Samarel. 2000.
Specialization at the Z line of Cardiac Myocytes. Cardiovascular Res. 46:277-285.
- Gowen, BB, RL Price, A Ghaffar and EP Mayer. 2000. Selective adhesion of macrophages to
denatured forms of type I collagen is mediated by scavenger receptors. Matrix Biology.
19:61-71.
- Ding, BO, RL Price, TK Borg, X Yan, PS Douglas, L Ma, EO Weinberg, T Thielen, J Bartunek
and BH Lorell. 2000. Left ventricular hypertrophy is ascending aortic stenosis mice:
anoikis and the progression to early failure. Circulation. 101:2854-2866.
- Yost, MJ, D Simpson, R Price, H Ploehn, S Ridley, T Borg and L Terracio. 2000. Method
for Treating Flexible Silicone Rubber Material to Enhance the Adhesion of Extra-Cellular
Matrix Proteins. Submitted to Am. Jo of Physiol, Heart & Circ. Physiol.
279:H3124-3130.
- Ross, RS, and TK Borg. 2001. Integrins and the Myocardium. Circ. Res. 88:1112-1119.
- Gowen, BB, TK Borg, A Ghaffar and EP Mayer. 2001. The collagenous domain of class A
scavenger receptors is involved in macrophage adhesion to collagens. J. Leukocyte Biology.
69:575-582.
- Goldsmith, EC, W Carver and TK Borg. 2001. The role of the extracellular matrix and its
receptors in modulating cardiac development. In: Formation of the Heart and its
Regulation. (R.J. Tomanek and R.B. Runyan, eds.) Bbirkhauser Press, Boston, MA.
- Sussman, MA, McCulloch, A, and Borg, TK. 2002. Dance band on the Titanic: biomechanical
signaling in cardiac hypertrophy. (review). Circulation Res. 91:888-898.
- Burgess, ML, Terracio, L, Hirozane, T, and Borg, TK. 2002. Differential integrin
expression by cardiac fibroblasts from hypertensive and exercise-trained rat hearts.
Cardiovascular Pathology 11:78-87.
- Goldsmith, EC, Carver, W. McFadden, A, Goldsmith, JG, Price, RL, Sussman, M, Lorell, BH,
Cooper, G. and Borg, TK. 2003.Integrin shedding as a mechanism of cellular adaptation
during cardiac growth. Am J. Physiol. In Press.
- Hunter, PJ and Borg, TK. 2003. Integration from proteins to organs:the physiome project.
Nature Reviews in Molecular and
Cell Biology: In press
- Goldsmith, EC, Hoffman, A, Morales, MO, Potts, JD. Price, RL, McFadden, A, Rice, M and
Borg, TK. 2004 Organization of fibroblasts in the heart. Developmental Dynamics In Press.
- Giurgiutiu, V, Friedman, Bender, J, Borg TK, Yost, MJ, Newcomb, W, Black A, Bost, J. and
Stewart CD. 2004 Electromechanical impedance sensor for in vivo monitoring the body
reaction to implants. J. Investigative Surgery log #3617.
- Guillermo Diaz-Araya, Borg, TK, Lavanero, S, Loftis, MJ and Carver, W. 2003. IGF-1
modulation of rat cardiac fibroblast behaviour and gene expression is age-dependent. Cell
Adhesion and Comunication 10:1-11.
- Peter J. Hunter and Borg, TK. 2003. Innovation: Integration from proteins to organs: the
Physiome Project. Nature Reviews in Molecular Cell Biology 4:237-243.
- Borg, TK. 2004. It's the Matrix! ECM, proteases and Cancer. Invited commentary. Amer. J.
Pathology 164:1141-1142.
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Education:
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Ph.D. -- Cell Biology, University of Wisconsin M.S. -- Zoology, Colorado State
University
B.S. -- Biology, Colorado State University |
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Contact Information:
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Phone: (803) 733-3115
Fax: (803) 733-1533
Borg@gw.med.sc.edu
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| Columbia, SC 29208 803-777-7000 info@sc.edu |
©
University of South Carolina Board of Trustees |
Cell and Developmental
Biology and Anatomy
Columbia, SC 29208
(803) 733-3159 --- (803) 733-3153 fax
Email Us at dba@gw.med.sc.edu |
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