Taixing Cui, PhD

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Research:

There are four areas of technical strengths in Dr. Cui’s laboratory: 1) molecular biology including most of the routine DNA, RNA and protein techniques; 2) cellular biology including primary culture of vascular smooth muscle cells, endothelial cells, macrophages and adipocytes, dissection of signal transduction pathways involved in cellular metabolism, migration and proliferation as well as inflammatory responses; 3) development and characterization of animal models of vascular disease through transgenic approaches; 4) vascular physiology analyses in cell, organ and whole animal levels.

Two major projects currently underway include:
1). Defining mechanism that regulates Keap1-mediated Nrf2 ubiquitination, degradation, anti-oxidative gene expression in vasculature.
2). Determining mechanism that controls the deubiquitinating enzymes such as UCH-L1- or CYLD-mediated suppression of inflammatory responses in vasculature.

Recent Publications:

1. Min LJ, Cui T, Yahata Y, Yamasaki K, Shiuchi T, Liu HW, Chen R, Li JM, Okumura M, Jinno T, Wu L, Iwai M, Nahmias C, Hashimoto K, Horiuchi M. Regulation of Collagen Synthesis in Mouse Skin Fibroblasts by Distinct Angiotensin II Receptor Subtypes. Endocrinology. 2004, 145:253-60.

2. Li JM, Cui T, Shiuchi T, Liu HW, Min LJ, Okumura M, Jinno T, Wu L, Iwai M, Horiuchi M. Nicotine Enhances Angiotensin II-induced Mitogenic Response in Vascular Smooth Muscle Cells and Fibroblasts. Arterioscler Thromb Vasc Biol. 2004,4:80-4.

3. Shiuchi T, Iwai M, Li HS, Wu L, Min LJ, Li JM, Okumura M, Cui T, Horiuchi M. Angiotensin II type-1 receptor blocker valsartan enhances insulin sensitivity in skeletal muscles of diabetic mice. Hypertension. 2004, 43:1003-10.

4. Nouet S, Amzallag N, Li JM, Louis S, Seitz I, Cui T, Alleaume AM, Di Benedetto M, Boden C, Masson M, Strosberg AD, Horiuchi M, Couraud PO, Nahmias C. Trans-inactivation of receptor tyrosine kinases by novel angiotensin II AT2 receptor-interacting protein, ATIP. J Biol Chem. 2004, 279:28989-97.

5. Zhang J, Fu M, Cui T, Xiong C, Xu K, Zhong W, Xiao Y, Floyd D, Liang J, Li E, Song Q, Chen YE. Selective disruption of PPARgamma 2 impairs the development of adipose tissue and insulin sensitivity. Proc Natl Acad Sci U S A. 2004, 101:10703-8.

6. Schopfer FJ, Lin Y, Baker PRS, Cui T, Garcia-Barrio M, Zhang J, Chen K, Chen YE, Freeman, BA. Nitrolinoleic acid—an endogenous PPAR? ligand. Proc. Natl. Acad. Sci. USA 2005, 102(7):2340-5.

7. Cui T, Schopfer FJ, Zhang J, Chen K, Baker PRS, Feng X, Agarwal A, Freeman BA, Chen YE. Nitrated Linoleic and Oleic acids; Endogenous Anti-inflammatory Signaling Mediators J Biol Chem. 2006, 281:35686-98

8. Villacorta L, Zhang J, Schopfer FJ, Baker PRS, Freeman BA, Chen YE, Cui T. Nitrated Linoleic acids inhibit proliferation of vascular smooth muscle cells via Keap1/Nrf2 pathways. Am J Physiol. 2007, 293(1):H770-6

9. Takami Y, Nakagami H, Morishita R, Katsuya T, Cui T, Ichikawa T, Saito Y, Hayashi H, Kikuchi Y, Nishikawa T, Baba Y, Yasuda O, Rakugi H, Ogihara T, Kaneda Y. Ubiquitin Carboxyl-Terminal Hydrolase L1, a Novel Deubiquitinating Enzyme in the Vasculature, Attenuates NF-?B Activation. Arterioscler Thromb Vasc Biol. 2007, 27(10):2184-90

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