Research:
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Dr. Gardner's major research emphasis is focused on understanding the pathogenesis of
heart failure. He has ongoing collaborations with Drs. Janicki and Brower in this
important area of research. Of particular interest are the mechanisms responsible for the
adverse cardiac remodeling associated with the progression of congestive heart failure. Current
topics of study include:
- the role of ovarian hormones and estrogen receptors in female cardioprotection,
- the role of cardiac mast cells, myocardial matrix metalloproteinases (MMPs) and
cytokines (i.e., TNF-alpha, IL-1beta, and IL-6) in myocardial remodeling,
- the temporal response of cardiac myocyte integrins during ventricular hypertrophy and
dilatation,
- the cardiac effects of inhaled particulate matter and cigarette smoke, and
- the dietary effects of soy isoflavones on cardiac remodeling.
Our laboratory utilizes primarily rodent models, including
models of hypertension and chronic ventricular volume
overload.
Research
Lab |
Recent Publications:
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Janicki J.S., G.L. Brower, J.D. Gardner, M.F. Forman, J.A. Stewart Jr,
D.B. Murray, A.L. Chancey. Cardiac mast cell regulation of matrix
metalloproteinase-related ventricular remodeling in chronic pressure or volume overload.
Cardiovasc Res., 69(3):657-65, 2006. [PDF]
Gardner, J.D., G.L. Brower and J.S. Janicki. Effects of dietary phytoestrogens on
cardiac remodeling secondary to chronic volume overload in female rats. J. Appl. Physiol.,
99(4):1378-83, 2005. [PDF]
Chancey A.L., J.D. Gardner, G.L. Brower and J.S. Janicki. Modulation of cardiac mast
cell mediated extracellular matrix degradation by estrogen. AJP: Heart and Circ.,
289(1):H316-21, 2005. [PDF]
Murray, D.B., J.D. Gardner, G.L. Brower and J.S. Janicki, Endothelin-1 Mediates Cardiac
Mast Cell Degranulation, MMP Activation and Myocardial Remodeling in Rats. AJP: Heart and
Circ., 287(5): H2295-H2299, 2004. [PDF]
Brower GL, Gardner JD and Janicki JS. Gender mediated cardiac protection from adverse
ventricular remodeling is abolished by ovariectomy. Mol Cell Biochem, 251:89-95, 2003. [PDF]
Gardner, J.D., G.L. Brower and J.S. Janicki. Gender differences in cardiac remodeling
secondary to chronic volume overload, J.Card. Failure, 8(2): 101-107, 2002. [PDF] |
