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Title:
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PUBMED Link:
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Goldsmith
EC |
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Research:
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Interactions between cells and the surrounding extracellular matrix (ECM) are
important in a variety of cellular processes including adhesion, migration, proliferation,
differentiation and apoptosis. Elucidating the factors that regulate and mediate these
interactions represents a fundamental step in understanding how the dynamic reciprocity
between cells and the ECM is mediated. The interaction of cells with the ECM is mediated
by cell surface receptors that are capable of binding a variety of ECM components. The
Discoidin Domain Receptors (DDR1 and DDR2) represent an additional pathway for
communicating information about the extracellular environment to the cell. DDRs represent
a novel group of receptor tyrosine kinases whose ligand is the ECM protein collagen. The
focus of my research is to understand the functional role of this new class of ECM
receptors, particularly DDR2, in cardiac development. The main focus currently is
exploring the role of DDR2 in mediating ECM remodeling during atrioventricular cushion
formation during early valve development. Questions we are interested in include how DDR2
interacts with the ECM, what effect this interaction has on the organization/structure of
the ECM along with potential changes in DDR2 expression and distribution, and what
information these receptors are capable of providing to the cell. We are also interested
in examining the potential interactive role that DDR2 may have with integrins in
regulating cardiac fibroblast response to the ECM. |
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Recent Publications:
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- Ding, B., R.L. Price, E.C. Goldsmith, T.K. Borg, X. Yan, P.S. Douglas, E.O. Weinberg, T.
Thielen, V.V. Didenko and B.H. Lorell. 2000. Left ventricular hypertrophy in ascending
aortic stenosis mice: Anoikis and the progression to early failure. Circulation
101:2854-2866.
- T.K. Borg, E.C. Goldsmith, R. Price, W. Carver, L. Terracio and A.M. Samarel. 2000.
Specialization at the Z line of Cardiac Myocytes, Cardiovascular Res. 46:277-285.
- E.C. Goldsmith, J.G. Davis, X. Yan, B.H. Lorell, T.K. Borg and R.L. Price. 2001. The
role of apoptosis in myocyte death during cardiac hypertrophy. Microsc. Microanal.
7:596-597.
- T.A. Bullard, E.C. Goldsmith and R.L. Price. 2001. Angiotensin II induces translocation
of protein kinase C a and e in neonatal rat cardiac myocytes. Microsc. Microanal.
7:1016-1017.
- E.C. Goldsmith, W. Carver and T.K. Borg. 2001 “The role of the extracellular
matrix and its receptors in modulating cardiac development”, in Formation of the
Heart and Its Regulation (R.J. Tomanek and R.B. Runyan, editors): 147-169.
- M. Watanabe, M. Hitomi, K. v.d.Wee, F. Rothenberg, S.A. Fisher, R. Zucker, K.K.H.
Svoboda, E.C. Goldsmith, K.M. Heiskanen and A. Hieminen. 2002. The pros and cons of
apoptosis assays for use in the study of cells, tissues and organs, Microsc. Microanal.
8(5): 375-391.
- Goldsmith E.C. and T.K. Borg. 2002. The dynamic interaction of the extracellular matrix
in cardiac remodeling. J. Card. Fail. 8: S314-318.
- Goldsmith E.C., W. Carver, A. McFadden, J.G. Goldsmith, R.L. Price, M. Sussman, B.H.
Lorell, G. Cooper and T.K. Borg. 2003. Integrin shedding as a mechanism of cellular
adaptation during cardiac growth. Am J. Physiol. Heart Circ Physiol .
284:H2227-2234.
- Price R.L., S.T. Haley, T.A. Bullard, E.C. Goldsmith, D.G. Simpson, T.E.Thielen and L.
Terracio. The effects of platelet-derived growth factor AA and BB on embryonic cardiac
development. Anat Rec. 2003 272A(1):424-33. .
- Goldsmith E.C., A. Hoffman, M.O. Morales, J.D. Potts, R.L. Price, A. McFadden, M. Rice
and T.K. Borg. 2004. Organization of Fibroblasts in the Heart. Devel. Dyn.
230:787-794.
- Morales, M.O., R.L. Price and E.C. Goldsmith. 2005. Expression of Discoidin Domain
Receptor 2 (DDR2) in the Developing Heart. Microsc. Microanal. 11:260-267.
- Orendorff, C.J., S.C. Baxter, E.C. Goldsmith and C.J. Murphy. 2005. Light scattering
from gold nanorods: tracking material deformation, Nanotechnology 16: 2601-2605 .
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Education:
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- 1990 B.S. Biochemistry College of Charleston, Charleston, SC
- 1996 Ph.D. Chemistry Univ. of North Carolina Chapel Hill, Chapel Hill, NC
- 1996-1998 Postdoctoral Fellow, University of South Carolina Department of Biology
- 1998-1999 Postdoctoral Fellow, University of South Carolina School of Medicine
- 2000-2002 Research Assistant Professor, University of South Carolina School of Medicine
- 2002-present Assistant Professor, University of South Carolina School of Medicine
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Contact Information:
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Email: ediegold@med.sc.edu
Phone: 803-733-1565
Address: Building1 Room B-20
USC School of Medicine
Columbia, SC 29209
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| Columbia, SC 29208 803-777-7000 info@sc.edu |
©
University of South Carolina Board of Trustees |
Cell and Developmental
Biology and Anatomy
Columbia, SC 29208
(803) 733-3159 --- (803) 733-3153 fax
Email Us at dba@gw.med.sc.edu |
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