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David B. Murray, Ph.D.
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Title:
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Research Assistant Professor |
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PUBMED Link:
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Murray
DB |
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Research:
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Dr. Murray’s major research emphasis is focused on understanding the progression
of deleterious ventricular remodeling known to occur in the pathogenesis of heart failure
as well as diabetes. He has ongoing collaborations with Drs. Janicki, Brower, Gardner and Baynes in this
important area of research. Of particular interest are the instigating circulating factors
(i.e. neurohormones and cytokines) responsible for this adverse cardiac remodeling. Current
topics of study include investigating the symmetry between diabetic cardiomyopathy and
heart failure by determining: 1) the role of autocrine and paracrine signaling messengers
in regulating cell-cell and cell-matrix interactions (specifically, cardiac mast cells and
ventricular fibroblasts) in myocardial remodeling, 2) the changes in myocardial matrix
components (i.e. total collagen and collagen type, and cross-linking), 3) the role of
advanced glycosylation endproducts (AGEs) and receptors for advanced glycosylation
endproducts (RAGE) in mediating cardiac remodeling and 4) determining the mechanism of
action for the antifibrotic effects brought about by anti-diabetic pharmacologic
treatments as well as the utilization of these treatments in non diabetic heart failure
patients.
Our laboratory utilizes primarily rodent models of heart failure;
including models of hypertension (ascending aortic banding)
and chronic ventricular volume overload (arteriovenous
fistula and myocardial infarction) and has experience
in both Type I and Type II diabetic models.
Research
Lab |
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Recent Publications:
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Cardiac mast cell regulation of matrix metalloproteinase-related ventricular
remodeling in chronic pressure or volume overload.
Janicki JS, Brower GL, Gardner JD, Forman MF, Stewart JA Jr, Murray DB, Chancey, AL. [PDF]
Modulation of cardiac mast cell-mediated extracellular matrix degradation by
estrogen. Chancey AL, Gardner JD, Murray DB, Brower GL, Janicki JS. [PDF]
Endothelin-1 mediates cardiac mast cell degranulation, matrix metalloproteinase
activation, and myocardial remodeling in rats. Murray DB, Gardner JD, Brower GL, Janicki
JS. [PDF]
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Education:
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- 1991-1995 University of Southern Mississippi – B.S. Cellular/Molecular Biology,
Minor- Biochemistry
- 1997-2002 East Carolina University SOM– Ph.D. Physiology
- 2002- 2005 Postdoctorate Fellow, Auburn University
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Contact Information:
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Cell and Developmental Biology & Anatomy
School of Medicine
University of South Carolina
Columbia, South Carolina 29208Office phone: (803) 733-3147
Email: dmurray@gw.med.sc.edu
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