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Lance Paulman, Ph.D.
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Title:
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| Research Associate Professor |
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Research:
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Dr. Paulman is interested in the interaction of between developing neural tissue with
extracellular matrix proteins. In particular, he is interested in the injury response of
the central nervous system. As wound repair in many highly differentiated systems requires
a recapitulation of developmental events, he is interested in discovering if this is true
in CNS as well. Currently, he is using an organotypic hippocampal culture system in which
he has characterized the postnatal expression of the ECM proteins laminin and fibronectin.
These studies are being used as a basis to examine changes in the patterns of expression
of these proteins following injury. He is also characterizing the expression of the
integrins, membrane-bound dimeric receptors for these ECM molecules, and determining how
their patterns of expression change following trauma in this model. He hopes that
this will lead to greater understanding of the cellular events that occur following trauma
in the CNS, with the aim of someday being able to apply this knowledge clinically to
persons with damage to the CNS. |
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Education:
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- 1989 B.S., Biology, Univ. South Carolina
- 1998 Ph.D., Biomedical Sciences/Developmental Biology, USC School of Medicine
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Contact Information:
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Email : Paulman@gw.med.sc.edu
Phone: (803) 733-1563
Fax: (803) 733-1533
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