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Ann Ramsdell, Ph.D.
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Title:
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PUBMED Link:
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Research:
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The focus of Dr. Ramsdell's lab is to determine the morphogenetic and molecular
mechanisms that direct generation of cardiac left-right asymmetry. Using both frog and
chick models to identify novel laterality genes, studies in Dr. Ramsdell's lab address how
the left-right body axis becomes established during early embryogenesis, how left-right
axial patterning information becomes transmitted to developing cardiac tissues, and how
the cardiac primordia interpret and respond to left-right positional cues. The ultimate
goal of this work is to advance our understanding of the etiology of congenital heart
defects, with an emphasis on the role that cardiac laterality genes play in overall
vertebrate heart morphogenesis. |
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Recent Publications:
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- Ramsdell A. F., Bernanke, J. M., and Trusk, T. C. (2005) Left-right lineage analysis of
the embryonic Xenopus heart reveals a novel framework linking congenital cardiac defects
and laterality disease. Development (in revision).
- Ramsdell, A.F. (2005). Left-right asymmetry and congenital cardiac defects: getting to
the heart of the matter in vertebrate left-right axis determination. Developmental Biology
288:1-20.
- Ramsdell, A. F., Bernanke, J. M., Johnson, J., and Trusk, T. C. (2005) Left-right
lineage analysis of AV cushion tissue in normal and laterality defective Xenopus hearts.
The Anatomical Record 287:1176-82.
- Tiedeken J., Ramsdell J.S., and Ramsdell, A.F. (2005) Developmental toxicity of domoic
acid in zebrafish (Danio rerio). Neurotoxicology and Teratology 27:711-7.
- Chen, Y., Whitaker, L. L., and Ramsdell, A. F. (2005) Developmental analysis of
activin-like kinase-4 (ALK4) expression in Xenopus laevis. Developmental Dynamics
232:393-398.
- Chen, Y., Mironova, E., Whitaker, L. L., Edwards, L., Yost, H. J., and Ramsdell, A. F.
(2004) ALK4 functions as a receptor for multiple TGF?-related ligands to regulate to
left-right axis determination and mesoderm induction in Xenopus. Developmental Biology
268:280-294.
- Ramsdell, A.F. and Yost, H.J. (1999) Cardiac looping and the vertebrate left-right axis:
antagonism of left-sided Vg1 activity by a right-sided ALK2-dependent BMP pathway.
Development 126: 5195-5205.
- Ramsdell, A.F. and Yost, H.J. (1998) Molecular mechanisms of vertebrate left-right
development. Trends in Genetics 14:459-465.
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Education:
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- 1991 B.S. College of Charleston, Charleston, SC
- Major: Biology Minor: Philosophy
- 1996 Ph.D. Medical University of South Carolina Graduate Program in Cell Biology and
Anatomy.
- 1997- 2000 Postdoctoral Fellow, University of Utah, Huntsman Cancer Institute Mentor: H.
Joseph Yost, Ph.D.
Area of Training: Developmental Biology ( Xenopus)
- 1999 Selected short course participant, American Heart Association’s
“Six-Day Symposium On Congenital Heart Disease, Embryology, Pathology, and
Cardiac Imaging”, Sept. 26-Oct. 1, Durham, NC
- 1997 Postdoctoral Fellow, Massachusetts General Hospital/Harvard Medical School,
Cardiovascular Research Center Mentor : Mark C. Fishman, M.D. Area of Training:
Developmental Biology (Zebrafish)
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Contact Information:
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Email: ramsdell@musc.edu
Phone: (843) 792-1620 Fax (843) 792-0664
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| Columbia, SC 29208 803-777-7000 info@sc.edu |
©
University of South Carolina Board of Trustees |
Cell and Developmental
Biology and Anatomy
Columbia, SC 29208
(803) 733-3159 --- (803) 733-3153 fax
Email Us at dba@gw.med.sc.edu |
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