Daping Fan

Daping Fan, M.D., Ph.D.

Associate Professor of Cell Biology & Anatomy
University of South Carolina School of Medicine

Contact:
Office:  803-216-3806
Lab:     803-216-3834
Fax:     803-216-3846
Email: daping.fan@uscmed.sc.edu

Pubmed

1992 Nanjing University School of Medicine – B.S. – Medicine
  1994 Nanjing University School of Medicine – M.D. – Clinical Medicine
  2004 Southern Illinois University – Ph.D. – Biochemistry & Molecular Biology

Research Focus

The rupture of vulnerable atherosclerotic plaques and the resulting thrombosis are the direct causes of heart attack and stroke, the No. 1 and No. 3 killers in the United States and many other developed countries. Atherosclerosis is both a lipid deposit disease and a chronic inflammatory condition. Macrophages are the primary cholesterol sinks as well as dominant inflammation machines in atherogenesis. Macrophage foam cell formation and inflammatory responses form a vicious cycle and promote atherogenesis. The goal of the research in our laboratory is to develop strategies to disrupt the vicious cycle and promote the regression of atherosclerotic plaques through restoring macrophage cholesterol homeostasis and controlling macrophage inflammation.

Myeloid cells are the major cell component of the tumor microenvironment (TME), whose interaction with malignant cells determines the aggressiveness of the tumor. Myeloid cells in TME are mainly myeloid-derived suppressor cells (MDSCs) and tumor-associated macrophages (TAMs). In advanced tumors, due to the unique features in TME including hypoxia, abundance in cytokines/chemokines and Toll-like receptor (TLR) ligands, and an unusual metabolic profile, a complex signaling network tunes the dynamics and function of the myeloid cells in favor of cancer progression. Our research is focused on understanding this signal network and developing strategies to manipulate it to improve cancer treatment.

Selected Recent Publications:

  1. Liang Fang, Johnie Hodge, Fatma Saaoud, Junfeng Wang, Stephen Iwanowycz, Yuzhen Wang, Yvonne Hui, Trent D. Evans, Babak Razani & Daping Fan. Transcriptional factor EB regulates macrophage polarization in the tumor microenvironment. OncoImmunology. 2017 Apr 20;6(5):e1312042. PMID: 28638736
  2. Ismail Sergin, Trent Evans, Xiangyu Zhang, Somashubhra Bhattacharya, Carl Stokes, Eric Song, Sahl Ali, Babak Dehestani, Karyn Holloway, Paul Micevych, Ali Javaheri, Jan Crowley, Andrea Ballabio, Joel Schilling, Slava Epelman, Conrad Weihl, Abhinav Diwan, Daping Fan, Mohamed Zayed, and Babak Razani. Exploiting Macrophage Autophagy-Lysosomal Biogenesis as a Therapy for Atherosclerosis. (2017) Nature Communications. 2017 Jun 7;8:15750. PMID: 28589926.
  3. Junfeng Wang, Stephen Iwanowycz, Fang Yu, Xuemei Jia, Shuilong Leng, Yuzhen Wang, Wei Li, Shiang Huang, Walden Ai, and Daping Fan. microRNA-155 deficiency impairs dendritic cell function in breast cancer. (2016) OncoImmunology 2016 Sep 9;5(11):e1232223. PMID: 27999745
  4. Shuilong Leng, Stephen Iwanowycz, Fatma Saaoud, Junfeng Wang, Yuzhen Wang, Ismail Sergin, Babak Razani, and Daping Fan. Ursolic acid enhances macrophage autophagy and attenuates atherogenesis. J. Lipid Res. 2016 June; 57(6): 1006–1016. PMID: 27063951. PMCID: PMC4878185
  5. Stephen Iwanowycz, Junfeng Wang, Johnie Hodge, Yuzhen Wang, Fang Yu, and Daping Fan. Emodin inhibits breast cancer growth by blocking the tumor-promoting feedforward loop between cancer cells and macrophages. (2016) Molecular Cancer Therapeutics. 15(8): 1931-42. PMID: 27196773
  6. Stephen Iwanowycz, Junfeng Wang, Diego Altomare, Yvonne Hui, and Daping Fan. Emodin bi-directionally modulates macrophage polarization and epigenetically regulates macrophage memory. (2016) J. Biol. Chem. 2016 Mar 23. pii: jbc.M115.702092. PMID: 27008857. PMCID: PMC4882421
  7. Junfeng Wang, Fang Yu, Xuemei Jia, Stephen Iwanowycz, Yuzhen Wang, Shiang Huang, Walden Ai and Daping Fan. MicroRNA-155 deficiency enhances the recruitment and functions of myeloid-derived suppressor cells in tumor microenvironment and promotes solid tumor growth. International Journal of Cancer, 2015 Mar 15;136(6):E602-13. PMID: 25143000
  8. Fen Du; Fang Yu; Yuzhen Wang; Yvonne Hui; Kevin Carnevale; Mingui Fu; Hong Lu; Daping Fan. microRNA-155 deficiency results in decreased macrophage inflammation and attenuated atherogenesis in apoE-/- mice. Arterioscler Thromb Vasc Biol. 2014 Apr; 34(4):759-769. PMID: 24504735 PMCID: PMC4036084
  9. Fen Du, Yvonne Hui, Michelle Zhang, MacRae Linton, Sergio Fazio, and Daping Fan. A Novel Domain Interaction Regulates Secretion of Proprotein Convertase Subtilisin/Kexin Type 9. (2011) J. Biol. Chem. 286:43054-61 PMID: 22027821
  10. Qiaoli Liang, Qinan Wu, Jihong Jiang, Jin’ao Duan , Chao Wang, Mark D. Smith, Hong Lu, Qian Wang, Prakash Nagarkatti and Daping Fan. Characterization of Sparstolonin B, a Chinese herb-derived compound as a selective Toll-like receptor antagonist with potent anti-inflammatory properties. (2011) J. Biol. Chem., 286:26470-9 PMID:21665946