Daping Fan

Daping Fan, M.D., Ph.D.

Associate Professor of Cell Biology & Anatomy
University of South Carolina School of Medicine

Contact:
Office:  803-216-3806
Lab:     803-216-3834
Fax:     803-216-3846
Email: daping.fan@uscmed.sc.edu

Pubmed

1992 Nanjing University School of Medicine – B.S. – Medicine
  1994 Nanjing University School of Medicine – M.D. – Clinical Medicine
  2004 Southern Illinois University – Ph.D. – Biochemistry & Molecular Biology

Research Focus

The rupture of vulnerable atherosclerotic plaques and the resulting thrombosis are the direct causes of heart attack and stroke, the No. 1 and No. 3 killers in the United States and many other developed countries. Atherosclerosis is both a lipid deposit disease and a chronic inflammatory condition. Macrophages are the primary cholesterol sinks as well as dominant inflammation machines in atherogenesis. Macrophage foam cell formation and inflammatory responses form a vicious cycle and promote atherogenesis. The goal of the research in our laboratory is to develop strategies to disrupt the vicious cycle and promote the regression of atherosclerotic plaques through restoring macrophage cholesterol homeostasis and controlling macrophage inflammation.

Myeloid cells are the major cell component of the tumor microenvironment (TME), whose interaction with malignant cells determines the aggressiveness of the tumor. Myeloid cells in TME are mainly myeloid-derived suppressor cells (MDSCs) and tumor-associated macrophages (TAMs). In advanced tumors, due to the unique features in TME including hypoxia, abundance in cytokines/chemokines and Toll-like receptor (TLR) ligands, and an unusual metabolic profile, a complex signaling network tunes the dynamics and function of the myeloid cells in favor of cancer progression. Our research is focused on understanding this signal network and developing strategies to manipulate it to improve cancer treatment.

Selected Recent Publications:

  • Liu Q, Li J, Liang Q, Wang D, Luo Y, Yu F, Janicki JS, Fan D. (2015) Sparstolonin B suppresses rat vascular smooth muscle cell proliferation, migration, inflammatory response and lipid accumulation. Vascul Pharmacol. 2015 Apr 11. pii: S1537-1891(15)00063-4. doi: 10.1016/j.vph.2015.03.015. [Epub ahead of print] PMID: 25869499

    Junfeng Wang, Fang Yu, Xuemei Jia, Stephen Iwanowycz, Yuzhen Wang, Shiang Huang, Walden Ai and Daping Fan. MicroRNA-155 deficiency enhances the recruitment and functions of myeloid-derived suppressor cells in tumor microenvironment and promotes solid tumor growth. International Journal of Cancer, 2015 Mar 15;136(6):E602-13. PMID: 25143000

    Fen Du; Fang Yu; Yuzhen Wang; Yvonne Hui; Kevin Carnevale; Mingui Fu; Hong Lu; Daping Fan. microRNA-155 deficiency results in decreased macrophage inflammation and attenuated atherogenesis in apoE-/- mice. Arterioscler Thromb Vasc Biol. 2014 Apr; 34(4):759-769. PMID: 24504735

    Jia X, Yu F, Wang J, Iwanowycz S, Saaoud F, Wang Y, Hu J, Wang Q, Fan D. (2014) Emodin suppresses pulmonary metastasis of breast cancer accompanied with decreased macrophage recruitment and M2 polarization in the lungs. Breast Cancer Res Treat. 2014 Nov;148(2):291-302. PMID: 25311112

    Fang Yu, Xuemei Jia, Fen Du, Junfeng Wang, Yuzhen Wang, Walden Ai, and Daping Fan. miR-155-Deficient Bone Marrow Promotes Tumor Metastasis. (2013) Molecular Cancer Research, 2013 Aug;11(8):923-36. doi: 10.1158/1541-7786.MCR-12-0686. Epub 2013 May 10. PMID: 23666369

    Hagai Tavori , Daping Fan, John L. Blakemore, Patricia G. Yancey, Lei Ding, MacRae F. Linton, and Sergio Fazio. Serum PCSK9 and cell surface low-density lipoprotein receptor: Evidence for a reciprocal regulation. (2013) Circulation. 127(24):2403-13. PMID: 23690465

    Shufeng Liu, Chao Qiu, Ruidong Miao, Jianhua Zhou, Aram Lee, Baoming Liu, Sandra N. Lester, Weihui Fu, Lingyan Zhu, Linxia Zhang, Jianqing Xu, Daping Fan, Kui Li, Mingui Fu, Tianyi Wang. (2013) PNAS. 110: 19083-8 PMID: 24191027

    Shufeng Liu, Kevin D. McCormick, Wentao Zhao, Ting Zhao, Daping Fan, Tianyi Wang. (2012) Human apolipoprotein E peptides inhibit hepatitis c virus entry by blocking virus binding. Hepatology 56:484-91 PMID: 22334503

    Qiaoli Liang, Qinan Wu, Jihong Jiang, Jin’ao Duan , Chao Wang, Mark D. Smith, Hong Lu, Qian Wang, Prakash Nagarkatti and Daping Fan. Characterization of Sparstolonin B, a Chinese herb-derived compound as a selective Toll-like receptor antagonist with potent anti-inflammatory properties. (2011) J. Biol. Chem., 286:26470-9 PMID:21665946

    Fen Du, Yvonne Hui, Michelle Zhang, MacRae Linton, Sergio Fazio, and Daping Fan. A Novel Domain Interaction Regulates Secretion of Proprotein Convertase Subtilisin/Kexin Type 9. (2011) J. Biol. Chem. 286:43054-61 PMID: 22027821