Edie C. Goldsmith, Ph.D.
Professor of Cell Biology & Anatomy
Biomedical Science Graduate Director
Director of the Postdoctoral Academic Career Development Program
University of South Carolina School of Medicine
||College of Charleston – Bachelors of Science – Biochemistry
||University of North Carolina, Chapel Hill – Ph.D. – Chemistry
||University of South Carolina– Post Doctoral Fellow – Biology & School of Medicine
The extracellular matrix (ECM) is a dynamic network consisting of structural proteins (collagens), glycoproteins and proteoglycans that provide a positional framework for cellular organization, cellular process cues (signals for proliferation, migration and differentiation) and a mechanism to transmit mechanical stimuli from one cell to another. Fibroblasts are the cell type largely responsible for the deposition and maintenance of the ECM in many organs and their transition into myofibroblast phenotype is associated with a number of fibrotic diseases in which excess ECM impairs normal organ function. Our interest is in understanding factors which affect the transition of fibroblasts into myofibroblasts and developing tools for regulating matrix production by these cells. We are currently examining fibroblast/myofibroblast behavior in the context of heart development and cancer. Of particular interest is the role that intercellular communication and local mechanical environment play in fibroblast/myofibroblast function. We have demonstrated that polyelectrolyte-coated gold nanorods have the ability to modulate collagen production and fibroblast transition into myofibroblast and are exploring the use of these particles in regulating additional cellular functions.
Sisco PN, Wilson CG, Chernak D, Clark JC, Grzincic EM, Ako-Asare K, Goldsmith EC, Murphy CJ (2014) Adsorption of cellular proteins to polyelectrolyte-functionalized gold nanorods: a mechanism for nanoparticle regulation of cell phenotype? PLoS One 9:e86670.
- Goldsmith EC, Bradshaw AD, Zile MR, Spinale FG (2014) Myocardial fibroblast-matrix interactions and potential therapeutic targets. J Mol Cell Cardiol 70:92-99.
- Chernak DJ, Sisco PN, Goldsmith EC, Baxter SC, Murphy CJ (2013) High-aspect-ratio gold nanorods: their synthesis and application to image cell-induced strain fields in collagen films. Methods Mol Biol. 1026:1-20.
- Fowlkes V, Wilson CG, Carver W, Goldsmith EC (2013) Mechanical loading promotes mast cell degranulation via RGD-integrin dependent pathways. J Biomech 46:788-795.
- Fowlkes V, Clark J, Fix C, Law BA, Morales MO, Qiao X, Ako-Asare K, Goldsmith JG, Carver W, Murray DB, Goldsmith EC (2013) Type II diabetes promotes a myofibroblast phenotype in cardiac fibroblasts. Life Sci 92:669-676.
- Goldsmith EC, Bradshaw AD, Spinale FG (2013) Cellular mechanisms of tissue fibrosis. 2. Contributory pathways leading to myocardial fibrosis: moving beyond collagen expression. Am J Physiol Cell Physiol 304:C393-402.
- Shuman JA, Zurcher JR, Sapp AA, Burdick JA, Gorman RC, Gorman JH 3rd, Goldsmith EC, Spinale FG (2013) Localized targeting of biomaterials following myocardial infarction: a foundation to build on. Trends Cardiovasc Med 23:301-311.
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