Joseph Janicki, Ph.D.

Joseph S. Janicki, Ph.D.

Professor of Cell Biology & Anatomy
Department of Cell Biology and Anatomy
School of Medicine

Office:  803-216-3810
Lab:     803-216-3839
Fax:     803-216-3846


1958-63 University of Delaware - B.S.- Physics
  1964-70 The Catholic University of America - M.S.E. in Fluid Mechanics Engineering
  1971-74 University of Alabama in Birmingham - Ph.D -. Physiology and Biophysics

Research Focus:

Dr. Janicki's research is focused on two aspects of cardiac remodeling secondary to abnormal pressure or volume loading conditions. The first deals with the role of the tissue renin-angiotensin system, including tissue angiotensin converting enzyme activity, in the cardiomyocyte hypertrophic response. The second involves the regulation of myocardial collagenase activity and the role that activated collagenase plays in progressive left ventricular dilatation. Ventricular enlargement, together with wall thinning and sphericalization, are features of chronic myocardial failure that contribute to its relentless downhill course. Preventing this adverse architectural and geometrical remodeling process is a major goal of this laboratory. These two research objectives are related in that hypertrophy is a major risk factor for heart failure. This research involves the use of animal models of hypertension, ventricular volume overload and heart failure, and several disciplines including organ and isolated myocyte physiology, biochemistry, pharmacology, morphometry and molecular biology.

Research Lab

Recent Publications

  • Li J, Jubair S, Janicki JS (2014) Estrogen Inhibits Mast Cell Chymase Release to Prevent Pressure Overload-Induced Adverse Cardiac Remodeling. Hypertension
  • Liu Q, Wang J, Liang Q, Wang D, Luo Y, Li J, Janicki JS, Fan D (2014)  Sparstolonin B attenuates hypoxia-reoxygenation-induced cardiomyocyte inflammation. Exp Biol Med (Maywood) 239:376-384.
  • Liu Q, Li J, Jubair S, Wang D, Luo Y, Fan D, Janicki JS (2014) Sparstolonin B attenuates hypoxia-induced apoptosis, necrosis and inflammation in cultured rat left ventricular tissue slices. Cardiovasc Drugs Ther 28:433-439.
  • Liu Q, Li J, Hartstone-Rose A, Wang J, Li Ji-Q, Janicki JS, Fan D (2014)  Chinese herbal compounds for the prevention and treatment of atherosclerosis: Experimental evidence and mechanisms.  Evid Based Comp Alt Med 1-15.
  • Li S, Wang W, Niu T, Wang H, Li B, Shao L, Lai Y, Li H, Janicki JS, Wang XL, Tang D, Cui T. (2014) Nrf2 deficiency exaggerates doxorubicin-induced cardiotoxicity and cardiac dysfunction. Oxid Med Cell Longev 2014:748524.
  • Li W, Wu W, Song H, Wang F, Li H, Chen L, Lai Y, Janicki JS, Ward KW, Meyer CJ, Wang XL, Tang D, Cui T (2014) Targeting Nrf2 by dihydro-CDDO-trifluoroethyl amide enhances autophagic clearance and viability of β-cells in a setting of oxidative stress. FEBS Lett 5;588:2115-2124.
  • Stewart JA Jr, Gardner JD, Brower GL, Janicki JS (2014) Temporal changes in integrin-mediated cardiomyocyte adhesion secondary to chronic cardiac volume overload in rats. Am J Physiol Heart Circ Physiol 306:H101-108. 
  • McLarty JL, Li J, Levick SP, Janicki JS (2013) Estrogen modulates the influence of cardiac inflammatory cells on function of cardiac fibroblasts. J Inflamm Res 6:99-108.
  • Janicki JS, Spinale FG, Levick SP (2013) Gender differences in non-ischemic myocardial remodeling: are they due to estrogen modulation of cardiac mast cells and/or membrane type 1 matrix metalloproteinase. Pflugers Arch 465(5):687-97.
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