Holly A. LaVoie, Ph.D.
Professor of Cell Biology & Anatomy
University of South Carolina School of Medicine
||College of William and Mary – Bachelors of Science, Biology, Minor in Anthropology
||College of William and Mary – Masters of Arts – Biology
||Medical College of Virginia – Ph.D. – Physiology
||University of Virginia – Post Doctoral Fellow – Molecular Biology and Endocrinology
Our lab studies the transcriptional control of genes mediating ovarian follicular growth, differentiation, and steroidogenesis in the ovary. We are interested in how specific transcription factors such as GATA4, GATA6, and C/EBPs control these processes. Our prior work implicated GATA factors in control of specific genes mediating steroidogenic processes. In particular the Steroidogenic Acute Regulatory protein STARD1, which controls the rate-limiting entry of cholesterol into the mitochondrion to initiate steroidogenesis, was identified as a GATA target in luteinized granulosa cells. Our lab uses in vitro molecular approaches to knockdown and overexpress transcription factors in primary cultures of porcine and human ovarian cells. These studies will promote a better understanding of normal ovarian function and disorders such as Polycystic Ovarian Syndrome and Luteal Insufficiency.
Another area of interest to our lab is how environmental chemicals affect endocrine and reproductive function. In recent studies of the flame-retardants Polybrominated diphenyl ethers (PBDEs), a low dose of these chemicals was found to alter specific endpoints in the thyroid and reproductive axes of perinatally exposed rats. These studies stress the need to remove these chemicals from the environment.
- LaVoie HA (2014) The GATA-keepers of ovarian development and folliculogenesis. Biol Reprod 91:38.
- Kumar A, Hu J, LaVoie HA, Walsh KB, DiPette DJ, Singh US (2014) Conformational changes and translocation of tissue-transglutaminase to the plasma membranes: role in cancer cell migration. BMC Cancer 14:256.
- LaVoie HA, Whitfield NE, Shi B, King SR, Bose HS, Hui YY (2014) STARD6 is expressed in steroidogenic cells of the ovary and can enhance de novo steroidogenesis. Exp Biol Med (Maywood). 239:430-435.
- Singh CK, Kumar A, Lavoie HA, Dipette DJ, Singh US (2013) Diabetic complications in pregnancy: is resveratrol a solution? Exp Biol Med (Maywood) 238(5):482-490.
- Kumar A, LaVoie HA, DiPette DJ, Singh US (2013) Ethanol neurotoxicity in the developing cerebellum: underlying mechanisms and implications. Brain Sci 3(2):941-963.
- Singh CK, Kumar A, LaVoie HA, DiPette DJ, Singh US (2012) Resveratrol prevents impairment in activation of retinoic acid receptors and MAP kinases in the embryos of a rodent model of diabetic embryopathy. Reprod Sci 19(9):949-961.
- King SR, LaVoie HA (2012) Gonadal transactivation of STARD1, CYP11A1 and HSD3B. Front Biosci (Landmark Ed) 17:824-846.
- Kumar, A, Singh, CK, LaVoie, HA, DiPette, DJ, Singh, US (2011) Resveratrol restores Nrf2 level and prevents ethanol-induced toxic effects in the cerebellum of a rodent model of fetal alcohol spectrum disorders. Mol. Pharmacol. 2011, 80:446-57.
- Blake, CA, McCoy, GL, Hui, YY, LaVoie, HA (2011) Perinatal exposure to low dose DE-71 increases serum thyroid hormones and gonadal osteopontin gene expression. Exp Biol Med 236:445-455, 2011. (Featured article)
- Singh, CK, Kumar, A, Hitchcock, D, Fan, D, Goodwin, R, LaVoie, HA, DiPette, DJ, Singh, US (2011) Resveratrol attenuates oxidative stress and prevents apoptosis in the embryos of diabetic dams; therapeutic implications in the prevention of diabetic embryopathy. Mol Nutr Food Res. 2011 55(8):1186-96.
- LaVoie, HA, Kordus, RJ, Nguyen, JB, Barth, JL, Hui YY (2010) GATA depletion impacts insulin-like growth factor 1 mRNA and protein levels in luteinizing porcine granulosa cells. Biol Reprod 83:1015-1026, 2010.
- LaVoie, HA and King, SR (2009). Transcriptional regulation of steroidogenic genes: STARD1, CYP11A1 and HSD3B. Exp Biol Med 234:880-907.