Susan M. Lessner, Ph.D.

Susan M. Lessner, Ph.D.

Associate Professor of Cell Biology & Anatomy
University of South Carolina School of Medicine

Contact:
Office: 803-216-3819
Lab:    803-216-3837
Fax:     803-216-3846
Email: susan.lessner@uscmed.sc.edu

Pubmed

1983 

Princeton University – Bachelors of Science in Engineering – Chemical Engineering
2000 Massachusetts Institute of Technology – Ph.D. – Chemical Engineering  
2003 Emory University – Post Doctoral Fellow – Division of Cardiology

Research Focus

Ak475_10x_8mos_WD_1and2ndIC2-2Dr. Lessner's research interests center on the vascular biology and biomechanics of atherosclerosis, with an emphasis on intraplaque angiogenesis (new blood vessel growth) and mechanical failure (plaque rupture).  Atherosclerotic plaque rupture is a leading cause of acute cardiovascular events such as heart attack and stroke.  Evidence available to date suggests that plaque rupture results from an adverse interaction between biomechanical and biological factors.  Research in our lab focuses on understanding both these types of factors and their interplay, in order to develop improved methods to reduce the incidence of plaque rupture and its harmful consequences.  In terms of the biology of plaque rupture, we focus in particular on the role of intraplaque angiogenesis, or new blood vessel growth, as a destabilizing factor in plaque growth. We also collaborate with faculty in Mechanical Engineering to develop constitutive models of normal and diseased arterial tissue.

Recent Publications

  • W. O. Twal, S. C. Klatt, K. Harikrishnan, E. Gerges, M. A. Cooley, T. C. Trusk, B. Zhou, M. G. Gabr, T. Shazly, S. M. Lessner, R. Markwald,  and  W. S. Argraves, “Cellularized microcarriers as adhesive building blocks for fabrication of tubular tissue constructs,” Ann. Biomed. Eng., 42(7), 1470-1481 (2014), on-line ahead of print 8/14/13, doi:10.1007/s10439-013-0883-6.
  • A. Sinha, A. Shaporev, N. Nosoudi, Y. Lei, A. Vertegel, S. Lessner, N. Vyavahare, “Nanoparticle targeting to diseased vasculature for imaging and therapy,” Nanomedicine, 10(5), 1003-1012 (2014), on-line ahead of print 2/22/14, doi:10.1016/j.nano.2014.02.002.
  • P. Badel, S. Avril, M. A. Sutton, and S. M. Lessner, “Numerical simulation of arterial dissection during balloon angioplasty of atherosclerotic coronary arteries,” J. Biomech., 47, 878-889 (2014).
  • Y. Wang, J. A. Johnson, F. G. Spinale, M. A. Sutton, and S. M. Lessner, "Quantitative Measurement of Dissection Resistance in Intimal and Medial Layers of Human Coronary Arteries," Exp. Mech., 54, 677–683 (2014), on-line ahead of print 12/5/13.
  • H. R. Bateman, Q. Liang, D. Fan, V. Rodriguez, and S. M. Lessner, “Sparstolonin B inhibits pro-angiogenic functions and blocks cell cycle progression in endothelial cells,” PLoS ONE, 8(8), e70500 (2013). doi:10.1371/journal.pone.0070500.
Click for older publications