Matrix Biology
The extracellular matrix (ECM) forms a 3-dimensional scaffold that plays an important
role in the development and maintenance of tissues and organs. While it has been known for
some time that the ECM has a critical structural role, more recent studies have shown that
it also regulates many cellular events including cell proliferation, migration,
differentiation and gene expression. Alterations in the organization or accumulation of
ECM components can dramatically affect organ formation and function. A number of faculty
in CDBA are actively investigating the mechanisms whereby the ECM is involved in tissue
organization, physiology and pathology. These researchers employ a wide range of in vivo
and in vitro models to unravel the role of the ECM in development and disease. Researchers
in CDBA are also performing studies utilizing ECM materials to engineer novel
3-dimensional tissue constructs. These studies will ultimately lead to the production of
improved materials for replacement of diseased and damaged tissues. Investigators in CDBA
involved in matrix research include:
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