Dr. Ramsdell's CV
Ann F. Ramsdell, Ph.D.
Associate Professor, Department of Cell Biology and Anatomy, University of South Carolina School of Medicine and Program in Women’s and Gender Studies, University of South Carolina College of Arts and Sciences
Member, Hollings Cancer Center
Adjunct Associate Professor, Department of Regenerative Medicine and Cell Biology, Medical University of South Carolina
USC office: 803-216-3892
MUSC office: 843-792-1620
||B.S. College of Charleston, Charleston, SC
Major: Biology Minor: Philosophy
||Ph.D. Medical University of South Carolina Graduate Program in Cell Biology and Anatomy.
||Postdoctoral Fellow, University of Utah, Huntsman Cancer Institute Mentor: H. Joseph Yost, Ph.D
My lab investigates how the vertebrate embryonic body plan becomes established and how positional information controls organ development and disease susceptibility. One of our particular interests is the role of left-right patterning in mammary gland development and breast cancer. Using in vivo and in vitro mouse models, we have been the first to show that mammary glands have baseline differences in cellular and molecular composition that are left-right independently regulated during normal and neoplastic development. Furthermore, we have found that the left-right differences identified in mouse models are predictive of breast cancer patient survival, suggesting that tumor laterality plays an important but underappreciated role in disease progression and outcome. Our most recent work focuses on epigenetic regulation of mammary stem cells and how this relates to left-right differences that arise during mammary development and mammary oncogenesis.
See Dr. Ramsdell recently speaking about her lab's research at TEDxColumbiaSC 2015
- Robichaux JP, Hallet RM, Fuseler JW, Hassell JA, Ramsdell AF. (2014) Mammary glands exhibit molecular laterality and undergo left-right asymmetric growth in MMTV-cNeu mice. Oncogene, in press PMID: 24909172
- *Fuseler JW, *Robichaux JP, Atiyah HI, Ramsdell AF. (2014) Morphometric and fractal dimension analysis identifies early neoplastic changes in mammary epithelium of MMTV-cNeu mice. Anticancer Research 34:1171-1177. PMCID: 24596356 *Equal contribution
- Velmaat JM, Ramsdell AF, Sterneck E. (2013) Positional variations in mammary gland development and cancer. Journal of Mammary Gland Biology and Neoplasia 18:179-88. PMCID: PMC3691492
- Martin LK, Mezentseva NV, Bernanke JM, Redmond MC, Ramsdell AF, Eisenberg CA, Eisenberg LM (2012) Inhibition of heart formation by lithium is an indirect result of the disruption of tissue organization within the embryo. Development, Growth and Differentiation 54:153-66. PMCID: PMC3288208
- Martin LK, Mezentseva NV, Bratoeva M, Ramsdell AF, Eisenberg CA, Eisenberg LM (2011) Canonical WNT signaling enhances stem cell expression in the developing heart without a corresponding inhibition of cardiogenic differentiation. Stem Cells and Development 20:1973-83. PMCID: PMC3202895
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