Francis G. Spinale, Ph.D., M.D.
Associate Dean, Research and Graduate Education
Distinguished Professor Emeritus of Personalized Medicine, Cell Biology and Anatomy, Surgery
University of South Carolina School of Medicine
Staff Physician and Scientist, WJB Dorn VA
1977-79 Northeastern University Bachelors of Science – Biology
1982-84 Medical University of South Carolina Masters of Science – Biometry
1985-88 Medical University of South Carolina Ph.D. – Pathology
1990-93 Medical University of South Carolina – M.D.
Biographical Information and Research Focus:
Francis G. Spinale (Frank) obtained both his MD and PhD from the Medical University of South Carolina, where he trained and served on the surgery faculty. He currently holds the position of Distinguished Professor Emeritus of Personalized Medicine in the Departments of Cell Biology & Anatomy and Surgery at USC School of Medicine and is also a Staff Physician-Scientist at the Wm. Jennings Bryan Dorn VA. More recently, he was appointed as Associate Dean of Research and Graduate Education at USC School of Medicine.
Dr. Spinale, an internationally renowned cardiovascular physician and scientist, has directed a translational research effort in the thematic area of cardiovascular disease, the main cause of death and disability in South Carolina, for over the past two decades.
He is also an entrepreneur and is currently engaged in biotechnology transfer and development efforts for 6 patents, which include biomarker profiling and diagnostics for strategic (personalized) treatment. Dr. Spinale serves on the editorial board of seven prestigious scientific journals, including Circulation, Circulation Research, and the American Journal of Physiology. He also has over 400 peer-reviewed publications in leading cardiovascular journals and is a fellow of several professional societies, including the American College of Cardiology and the American Association for Thoracic Surgeons. Further, Dr. Spinale is an award-winning educator with an impressive teaching/research training record. To this end, he has recently been honored with both the Breakthrough Leadership in Research Award and the Educational Foundation Research Award in Health Sciences at USC.
Dr. Spinale has pioneered various projects for cardiac research while working to collaborate with other departments and faculty. The National Institutes of Health (NIH), the Veterans Administration (VA), and several pharmaceutical companies have also funded his research. The mechanistic, translational, and clinical studies he has been working on will advance our understanding and potential treatment for major causes of heart failure in patients.
- Zhou B, Prim DA, Romito EJ, McNamara LP, Spinale FG, Shazly T, Eberth JF. Contractile smooth muscle and active stress generation in porcine common carotids. J Biomech Eng. 2018 Jan 1;140(1).
- Spinale FG, Sapp AA. Cardiovascular risk and matrix metalloproteinase polymorphisms: not just a simple substitution. Editorial based on, "Genetic variants contributing to circulating matrix metalloproteinase 8 levels and their association with cardiovascular diseases: a genome-wide analysis" by Salminen et al. Circ Cardiovasc Genet. 2017 Dec;10(6):e001958.
- Barlow SC, Doviak H, Jacobs J, Logdon CB, Perreault PE, Zellars KN, Moreau K, Villacreses CF, Smith S, Khakoo AY, Lee T, Spinale FG. Intracoronary delivery of recombinant TIMP-3 following myocardial infarction: effects on myocardial remodeling and function. Am J Physiol Heart Circ Physiol. 2017 Jul 28. APSselect, 2017 September.
- Romito E, Shazly T, Spinale FG. In-vivo assessment of regional mechanics post-myocardial infarction: a focus on the road ahead. J Appl Physiol. 2017 Feb 23.
- Spinale FG, Frangogiannis NG, Hinz B, Holmes JW, Kassiri Z, Lindsey ML. Editorial: Crossing into the next frontier of cardiac extracellular matrix research. Circ Res. 2016 Oct 28;119(10):1040-1045.
- Spinale FG. Editorial on "Injectable Shear-Thinning Hydrogels for Minimally Invasive Delivery to Infarcted Myocardium to Limit Left-Ventricular Remodeling”: Improving Delivery of a Biomaterial Payload in MI. Circ Cardiovasc Interv. Circ Cardiovasc Interv. 2016 Oct;9(10).
- Romito E, Doviak H, Logdon C, Freels PD, Shazly TE, Spinale FG. Sonomicrometry-based analysis of post-myocardial infarction regional mechanics. Ann Biomed Eng. 2016 Jul 13. PMID: 27411709
- Suzuki K, Satoh K, Ikeda S, Sunamura S, Otsuki T, Satoh T, Kikuchi N, Omura J, Kurosawa R, Nogi M, Numano K, Sugimura K, Aoki T, Tatebe S, Miyata S, Mukherjee R, Spinale FG, Kadomatsu K, Shimokawa H. Basigin promotes cardiac fibrosis and failure in response to chronic pressure-overload in mice. Arterioscler Thromb Vasc Biol. 2016 Apr;36(4):636-46. PMID: 26916734
- Gopinathannair R, Etheridge SP, Marchlinksi FE, Spinale FG, Lakkireddy D, Olshansky B. Arrhythmia-induced cardiomyopathies: mechanisms, recognition and management. J Am Coll Cardiol. 2015 Oct 13;66(15):1714-28. PMID: 26449143
- Bolger AF, Spinale FG. Fate versus flow: wall shear stress in the aortopathy associated with bicuspid aortic valves. J Am Coll Cardiol. 2015 Aug 25;66(8):901-4.
- Spinale FG, Gorman RC, Burdick JA. Author response: New therapies for reducing post-myocardial left ventricular remodeling. Ann Transl Med. 2015 Jun;3(10):146. PMCID: PMC4486917
- Mani SK, Kern CB, Kimbrough D, Addy B, Kasiganesan H, Rivers WT, Patel RK, Chou JC, Spinale FG, Mukherjee R, Menick DR. Inhibition of class I histone deacetylase activity represses matrix metalloproteinase-2 and -9 expression and preserves LV function post myocardial infarction. Am J Physiol Heart Circ Physiol. 2015 Jun 1;308(11):H1391-401. PMCID: PMC4451303
- Spinale FG. Assessment of cardiac function - basic principles and approaches. Compr Physiol. 2015 Sep 20;5(4):1911-46. PMID: 26426471
- McGarvey JR, Kondo N, Witschey WR, Takebe M, Aoki C, Burdick JA, Spinale FG, Gorman JH 3rd, Pilla JJ, Gorman RC. Injectable microsphere gel progressively improves global ventricular function, regional contractile strain, and mitral regurgitation after myocardial infarction. Ann Thorac Surg. 2015 Feb;99(2):597-603. PMCID: PMC4314332
- McGarvey JR, Pettaway S, Shuman JA, Novack CP, Zellars KN, Freels PD, Echols Jr. RL, Burdick JA. Gorman JH, Gorman RC, Spinale FG. Targeted injection of a biocomposite material alters macrophage and fibroblast phenotype and function following myocardial infarction: relation to LV remodeling. J Pharmacol Exp Ther. 2014 Sep;350(3):701-9. PMCID: PMC4152878
- Spinale FG. Myocardial basis for heart failure: role of cardiac interstitium. Mann/Heart Failure: A Companion to Braunwald's Heart Disease. Editor: Mann DL. Saunders, Philadelphia, PA; 2014, 62-77.